Winona fire units were called to a residence on the east end on a report of fire Tuesday morning.
A witness told Winona Radio News the fire was at 154 High Forest and that all off duty firefighters were called in.
Smoke was seen coming form the residence which was believed to be unoccupied.
Some streets in the area were blocked off including Third Street from Mankato Avenue to St. Charles Street.
The fire was reported just after 6:00 a.m.